Since the first method didn't work I gave it a shot, but I'd prefer the first with the timecode converter. The input indicator clearly shows Lockstep is getting the signal, however I have no visual clue if it is doing anything and Logic doesn't start playing eiter. Logic doesn't start playback (sync enabled, playhead is blue)Ģ MT8X is striped with Millumin time clock generator (it is an app that is generating time code signal), the timecode signal goes back to the audio interface (audio in) and Figure 53 Studio - Lockstep is listening to the signal (audio in) and convert it to MTC. The YMC10 is connected to my audio interface with five pin MIDI and listens to midi clock, as I start Logic it spits out the signal (or at least it does something I can hear) so I can record it to the multitrack (track 8, sync signal level set to -3dB, dbx off) When all set YMC10 can convert the recorded SMPTE to MIDI time code, as it is happening I can see the incoming MIDI led is blinking on my audio interface. So I tried two methods to sync Logic to tape, none of the would start logic when sync is enabled:ġ MT8X striped with the sync signal with a Yamaha YMC10 MIDI/SMPTE converter. I read multiple threads, watched videos whilst researching this topic/issue but no luck yet. – Design your layout with vector-based objects for maximum precision and flexibility.I'd like to sync logic to a Yamaha MT8X multitrack recorder but it doesn't work. – ELM: ENTTEC LED MAPPER provides total control over your LED system, regardless of shape and size. – 1 RS232 input for profile selection via serial command – 24 PLink output ports on RJ45 (Pixel Link Data) – The revolutionary Profile Editor is the easiest way to configure each of the 24 ports to behave the way you need to. – Create, edit or copy your own profile to suit the requirements of your project and view the input data stream live (using the Stream Auditor Licence). – Use any modern web browser to manage your Pixelator. – Why settle for slow clunky units, when the Pixelator is the best choice for Pixel mapping installations, around the globe. – Fast blazing memory to suit the immense processing power, ensures a brilliant output at all times. – The following protocols are fully compatible with Pixelator and Plink system. Supports a wide range of Pixel tape and dots. – Efficient and revolutionary, the Pixelator has the best brain and eats major Ethernet protocols for breakfast, lunch and dinner to bring you 24/7 performance that never gives up or lets you down. – This processor is exactly what you need if you want to receive a mixture of input protocols and output to thousands of pixels and ensure that they are always synchronized with the input. – The Pixelator has the power to output 8160 pixels in total, thanks to brilliant ENTTEC engineering. – Outstanding performance, with rock-solid LED pixel mapping, and perfect synchronization across 24 outlets in Sync mode. – The only Gigabit pixel converter in the world. No other device on the market offers this level of performance. Only the Pixelator lets you do a lot more with less fuss at a lower cost.Back up or restore your profiles for fast deployment across many units to wow even the largest audience.Set the Pixelator’s 24 ports to behave exactly as you need them to with ease.All of this can be configured using ENTTEC’s local host profile editor.As a result, you’ll experience no image ghosting or tearing of your pixel-mapped content.For instance, the ability to allow different types of protocol to be sent to different locations yet remain in sync.This Ethernet-to-Pixel converter has many key distinguishing features.
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POSTWAR: A HISTORY OF EUROPE SINCE 1945 by Tony Judt.OUT OF SHEER RAGE: WRESTLING WITH D.H.MANUFACTURING CONSENT by Noam Chomsky and Edward Herman.LIGHTS OUT FOR THE TERRITORY by Iain Sinclair.IMPRESSIONISM: ART, LEISURE AND PARISIAN SOCIETY by Robert L.FOOTSTEPS: ADVENTURES OF A ROMANTIC BIOGRAPHER by Richard Holmes.FICTION AND THE FIGURES OF LIFE by William H.EXISTENTIALISM FROM DOSTOYEVSKY TO SARTRE edited by Walter Kaufmann.BASIC WRITINGS ON POLITICS AND PHILOSOPHY by Karl Marx and Friedrich Engels.A PEOPLE'S HISTORY OF THE UNITED STATES by Howard Zinn.A HISTORY OF NARRATIVE FILM by David A.A TOMB FOR BORIS DAVIDOVICH by Danilo Kis.Lezama, Arenas, Beauty and Dictatorship: A Quote f.The Paris Review Interviews and KCRW's 'Bookworm'.FIRST LOVE AND OTHER SORROWS by Harold Brodkey."Time and Narrative in A la Recherche du Temps Per.Ezra Pound's WWII radio broadcast scripts online.Just listen to the first two questions he asks Sebald, and then ask yourself, "Why doesn't this guy have a show on PBS?" (America's best writers deserve better than a few predictable minutes around Charlie Rose's big round table.) Check out the Bookworm archive-but be warned: it's a labyrinth of Daedalus, and you might not find your way out. And Silverblatt is a very good interviewer, knowledgeable and impressively well-read. Gass, and just about anyone else a serious reader wants to hear seriously interviewed. Vollmann, David Foster Wallace, Alexander Theroux, William H. Sebald (listen to his gorgeous Germano-British accent), Camille Paglia (who gives new meaning to the word 'motormouth ' she seems to have downed a bottle of amphetamines with a Jolt Cola chaser immediately before her 1993 interview), William T. " Here you can listen to twenty years worth of highly informative 30-minute interviews with the likes of W. Less well-known is the enormous online archive of audio interviews recorded for Michael Silverblatt's gloriously highbrow and unapologetically intelligent KCRW radio program " Bookworm. I'll probably be reading my way at random through many of the others over the next several years. (More fool me for buying two volumes of these interviews a couple of years ago.) The Harold Bloom interview is especially enjoyable. Most readers already know that a large number of the classic Paris Review Interviews can be read online at no charge. I've been spending altogether too much time recently digging around in a couple of amazing online literary interview archives. that there might be one list which would show _all_ devices, labeled. insert smart sim on globe pocket wifi ) go to 192. Blocked devices will be displayed in the Blocked Wi-Fi device (s) panel. Following the first generation 5G router ZTE MC801, ZTE MC801A is a compact and powerful 2nd generation 5G router that lets you easily connect a high-speed connection to your.Option one: Open Settings > About Tablet > Status > Serial Number. 1 on the Host Name (or IP address) and 22 on the Port field. New workplaces, new food sources, new medicine-even an entirely new economic system. We will inform you when the Globe iPhone unlock. The firmware on the AN5506-04-FA device is vulnerable to a remote stack overflow in the webs process by sending a Cookie value with a length > 511 bytes to any valid asp webpage. Enter the IMEI in the text box and click "Calc", Step 5. The HG6245D and the AN5506-04-FA devices share a very similar code base.”, Permanent free Unlocking of Globe Philippines Huawei E586Es-2 is possible using an unlock code. It will prompt to enter Insert other SIM to your pocket WIFI (ex. After logging in, click the Device Settings tab. either "Allowed" or "Blocked", depending. Hi Everyone, Welcome to Information Technology Channel!In this video, Im gonna tech you of how to block and Unblock users on your Globe Home Broadband. insert SMART SIM on Globe pocket WIFI) Go to 192. 25 4 or to initiate this process we need the serial number and Lenel OnGuard GO-Software Lenel OnGuard GO-Software Access control software Technical Specification. Enter your payment details using our payment service provider. Reset the device, even replace the antenna and no difference. Two games into the season isn’t optimal timing to be nursing this many maladies already, and the Spartans need to get as healthy as possible for the trip to Washington.Ĭontact Chris Solari. Jim Harbaugh and the Michigan Wolverines have started the 2022 season off with two blowout victories over lesser competition at the Big House a 51-7 win against Colorado State in Week 1, and a. After the storms had passed through Ann Arbor on Saturday night, the two most important people in Michigan Stadium. Michigan football: One ugly win doesnt detroit free press wolverines. Michigan football: One ugly win doesnt detroit free press wolverines. McCarthy put on a show for 5-star QB recruit Jadyn Davis. Shop the finest selection of detroit free press wolverines, 50 Discount Last 3. MSU lost defensive tackles Jacob Slade and Maverick Hansen and safety Angelo Grose at points to in-game injuries, and Thorne sat out a drive after taking a crunching hit on his second interception. Shop the cheapest selection of detroit free press wolverines, 54 Discount Last 2. Defensive line coach Mike Elston, who was hired last month, also will add duties as the program’s recruiting coordinator. Harbaugh said he hopes to maintain the relationship with IGNITE, Swanson and the jail into the future. He will continue to work with the defensive backs. Henderson and Snow already were out, as were defensive tackles Dashaun Mallory and Jalen Hunt among others on the defense. Following the game, a Detroit newspaper described Notre Dames predominantly Irish-American lineup as a group of Fighting Irishmen, giving birth to the. The Wolverines will have more service opportunities on their tour, which runs through July 29. Watch breaking news live or see the latest videos from. ∙ Team health: Tucker didn’t specify Jayden Reed’s injury, which knocked him out of the game in the first half after he crashed hard into Akron’s bench. Detroit news, weather, sports, and traffic serving all of southeast Michigan and Metro Detroit. The Wolverines scored a commitment Monday from four-star offensive tackle Evan Link from Gonzaga High School. The transfer of Justin Boren to Ohio State is an old story for the Michigan football program. He finished with two tackles, one of them for a 9-yard loss, but finding snaps behind those three veterans right now is a challenge for the sophomore. A run of misfortune for Michigan football ’s offensive line recruiting is finally over. McCarthy will pull away in the QB race and what will be considered successful for Jim Harbaugh in 2022. Gaoteote, Mel Tucker’s first four-star signing in the 2021 class, didn’t get in until the game was well in hand. This week, the guys are joined by Free Press Michigan football beat writer Michael Cohen, who shares his thoughts on how the Wolverines will follow up their Big Ten championship season, whether Cade McNamara or J.J. ∙ LB Ma’a Gaoteote: Even with Darius Snow out, the Spartans primarily used just three linebackers - Ben VanSumeren and Cal Haladay started, with Aaron Brule rotating in - for most of the game. Rainer Sabin, Detroit Free Press September 3, 2022, 3:44 PM 4 min read Free Press sports writer Rainer Sabin answers three questions after Michigan football defeated Colorado State, 51-7, in. He now has three interceptions on the season and four touchdowns after just his second time as a starter not throwing a scoring pass. © 2019 Detroit Lions, Ltd.Thorne had two against Akron on Saturday, both of which came when he got hit on blitzes and tried to force a throw rather than taking a sack. No portion of this site may be reproduced without the express written permission of the Detroit Lions. 'best i've seen defense run to the football' harbaugh said since he's been at UM by angelique via twitter 4:24:26 PM Harbaugh says that's the best he's seen a Michigan defense run to the ball since he's been back here. Htag.Applying ROT13 to a piece of text merely requires examining its alphabetic characters and replacing each one by the letter 13 places further along in the alphabet, wrapping back to the beginning if necessary. Htag = document.querySelector('.green-h3') Let htag = document.querySelector('.green-h3') If then # SQLQUERY contains an empty string.Įcho "There have been no new documents added to the CMS in the last 7 days." > /root/bin/mailtextĬonst jobContainer = document.querySelector('.job-description') I mean:Įcho "TO:" $RECIPIENTS > /root/bin/mailtextĮcho "SUBJECT:" $SUBJECT $DATE > /root/bin/mailtextĮcho "SELECT name AS NAME,MIN(id) as ID,MIN(created_at) as CREATED,MIN(CONCAT(' as URL from pages WHERE deleted_at IS NULL AND name NOT LIKE 'AO%' AND name NOT LIKE 'KB%' AND name NOT LIKE 'Odoo%' AND name NOT LIKE 'WK%' AND draft=0 AND created_at > DATE_SUB(NOW(), INTERVAL 7 DAY) GROUP BY name \G" | mysql -u root -D bookstack > /root/bin/mailtextĬat /root/bin/mailtext | /usr/sbin/sendmail -tĭATE=$(date DATE_SUB(NOW(), INTERVAL 7 DAY) GROUP BY name \G" | mysql -u root -D bookstack)Įcho "FROM:" $SENDER > /root/bin/mailtext Was this a classic SingleEntityAuthorUsers relationship I would have build it as a ManyToMany item, but here it's different.Īuthor would probably contain two ManyToOne relations (one with the User entity and one with either the Document or the Video entity) plus the entity type field, but I really don't know how to code the "Document orVideo`" part. The problem is that I cannot understand how to build this in Doctrine.
The traditional method of creating a home inventory is to make a list of all your belongings on paper, supplementing it with photos, videos, valuations, and receipts. Get in the habit of addressing your home inventory needs every year at this time, and you’ll be protected in the event disaster strikes. The excitement of the holidays will be over yet you can still easily locate receipts from big-ticket purchases-many of which are made between Black Friday and Christmas. January is the ideal time to create or update your home inventory. Photo: When Should You Compile an Inventory? In that case, your home inventory can serve as evidence of the value of your collection, and you’ll be able to purchase a rider to your policy that specifically covers the art at a higher reimbursement value. If you collect original art, for instance, the value of your collection may well exceed your policy’s coverage limit for personal belongings. In addition to helping you file a claim that truly reflects the value of your property, a home inventory can be instrumental in obtaining more insurance coverage. And once you accept reimbursement from your insurance company, you can’t make additional claims. It’s fairly easy to remember large items, such as big screen TVs and the grandfather’s clock in your living room, but could you name every necklace in your jewelry box without looking? If you had to list all your valuables after a natural disaster or property crime, it’s likely you wouldn’t remember all of them. Here, answer to all your questions about a home inventory-and helpful pointers on how to get it done. Now’s the time to compile that essential inventory so you can start the year with a greater sense of security that your personal property will be protected. Without a home inventory prepared in advance, that list would need to be pieced together from memory. In the stressful aftermath of a disaster, could you count on your memory to recall what items have been lost and what they were worth? If not, you’ll likely get less compensation than you deserve. But should such a disaster occur, you’d need to provide your insurance company with a detailed list of your belongings in order to be reimbursed for lost or damaged items. “Homeowners who set aside time to complete a home inventory have a much easier time documenting their losses and filing a claim, if and when they have to do so,” says Michael Barry, a spokesperson at the industry-sponsored Insurance Information Institute, based in New York City.No one likes to think about the possibility of fire, flood, storm damage, or theft. Without a record of your belongings, remembering what you’ve lost can be a challenge anytime, let alone during a time of trauma. After a fire, wind storm, robbery or other unexpected event, having a list or a visual reminder of your belongings can make a big difference in how much your homeowners insurance will pay, and thus how well you’ll recover financially. What's more? You better prepare yourself for an emergency. With the space those discards leave, you may be able to better rearrange what's left. You may identify items you can throw out. For one, you may find things you thought were missing. The process only takes a few hours, but it has long-lasting benefits. If your New Year's resolutions include getting organized, consider doing a home inventory. It includes live music from the best local and national bands as well as Halloween-themed entertainment. The Ultimate Halloween Fest is a massive event, running on the weekends in September and October. Ultimate Halloween Fest (October 29–30, 2022) After the parade, visitors can stroll through craft booths, food vendors and listen to live music. The parade features floats, colorful decorations, music bands, and funny characters marching through the Highlands. The parade usually starts on Baxter Avenue and continues to Bardstown Road, in the heart of the Highlands neighborhood, the epicenter of Louisville's nightlife as well as bar and restaurant scene. Louisville Halloween Parade is the largest fall celebration in the city, which attracts over 45,000 attendees. Louisville Halloween Parade (October 29–30, 2022) The Jack-O-Lantern Spectacular also includes entertainment for the whole family and themed scenes with music. Held in Iroquois Park, this fall light extravaganza features 5,000 carved pumpkins, illuminated right after dusk and will glow till midnight. The Jack-O-Lantern Spectacular is one of the best annual light displays in Louisville and is suitable for all ages. Louisville Jack-O-Lantern Spectacular (October 4–31, 2022) What started as a friendly competition between neighbors has grown into a popular attraction, which draws crowds of children and adults. Since the 1980s, Hillcrest Avenue residents have been very serious about their Halloween décor. Halloween decorations in this residential area attract visitors from all over Louisville. Ĭorrection: An earlier version of this story incorrectly stated the number of people who attended last year’s event.One of the best areas in the city to get into the Halloween spirit is the Hillcrest neighborhood. More information and tickets are on the event website here. There will also be a special night on November 2 designed for people with autism spectrum disorders and sensory processing differences. Tickets start at $14 for adults and $10 for children. Louisville’s Jack-O-Lantern Spectacular starts Tuesday and lasts through November 3. “You cherish those times like, ‘God, I used to get so mad at my dad when he would do it.’ I would give anything to have him do it one more time.”Īnd someday, maybe his kids will hassle him for talking about pumpkins on Christmas. “Isn’t that amazing, how it is a cycle? History repeats itself,” Reckner said. Until then, Reckner plans to focus on each event and to carve pumpkins in his spare time like his dad does. Reckner now has four kids who he hopes will carve pumpkins with their grandpa someday. “Then before long it went to a couple of thousand pumpkins for a week.”Īrtist carves for Louisville’s 7th Jack-O-Lantern Spectacular Then a couple hundred pumpkins turned into 500, and one night turned into two nights,” Reckner said. “The carving would get more elaborate and we would add more pumpkins. When other cities noticed and asked the family to bring the fundraiser to them, their business grew. “‘We can turn it into a fundraiser for the school system.’”īack then, Reckner said his friends and family would work 120 hours a week carving pumpkins and organizing similar fundraisers in Oxford. “My dad was like, ‘God, we should do something like this in Oxford,’” Reckner said. On a family trip to Vermont when Reckner was 15, the family found a local farm was using a jack-o’-lantern display to raise money. He said his dad even talks about pumpkins during Christmas. Reckner said his dad is obsessed with pumpkins, and would spend days vacationing from his job as a mailman to carve them. If you ask him how the family’s modest fundraiser expanded to three events that involve more than 15,000 pumpkins in total, he will tell you about a trip to Vermont. Reckner has carved pumpkins since his family’s first jack-o’-lantern fundraiser in 1988. Reckner, a 47-year-old Oxford, Massachusetts native, is the co-founder of what’s now a company that produces jack-o’-lantern fundraisers in three states - including the Jack-O’-Lantern Spectacular that kicks off in Louisville’s Iroquois Park on Tuesday. Travis Reckner loves to talk about pumpkins, and even dreams about them. The puzzle follows similarly to an archaeological dig. She will give you several tools if you don't have them already. Speak to the Archeologist and she will instruct you to start digging out the site. You and her will leave the Town Hall and speak. She will begin to struggle to think of an answer, and say that you are one of the main diggers and that her team will arrive soon. Thinking this is a pretty legitimate statement, the Mayor will grant her permission and the museum. The Archaeologist will then convince him that she means no harm to him nor Nardah, and that she respects history as much as the next historian. Head to Nardah and speak to Awusah the Mayor.Īwusah will say that he is indeed happy to see someone come all the way down from Varrock to help with an important dig, but is pretty sceptical about it, after hearing what other "archaeologists" do. But her main issue is namely trying to find Nardah so she can discuss this from the locals and hopefully have permission from them to do the dig. Proceed to approach the woman and she will tell you that she is an archaeologist for the Museum of Varrock by the name of Rein Nada, and she apparently is lost and needs your assistance in helping her unearth an ancient temple for research purposes. They will tell you to stop and ask you for directions. Travel north of Nardah and keep walking north until you see someone. Items from the toolbelt are not listed unless they do not work or are not automatically added.įor all dialogue, see A Tale in the Desert/Dialogue. Talk to the archaeologist north of Nardah. The Quest Series will surround around Elidinis' arrival back on Gielinor, which will link to the main Desert Quest series. Mod Milton had stated he promised to give Pollnivneach a graphical update upon the release of the second quest. The river had also seen a large stretch to fit in the Hippo. The Elid River was also updated as a result of this update adding in a new slayer monster, the Hippopotamus (requires level 60 Slayer), and gave Crocodiles swimming animations as well as Lizards (in addition to their ability to swim in the Elid). Upon the release of this quest, Nardah and its inhabitants received a graphic makeover and its music updated. This quest introduces the ground basics of the history of Nardah, namely its founder, Nardarine and the goddess Elidinis herself. A Tale in the Desert is the first quest in the Nardarine quest series. Rocky Mountain Power partners with agencies to bring additional resources for attracting top companies and high-paying jobs and to help existing companies expand. By working closely with state and local development organizations, Rocky Mountain Power helps communities enhance their economic vitality. Rocky Mountain Power is committed to making communities stronger, cleaner and safer places to live and work. Rocky Mountain Power & Economic Development The company continues to invest to meet customers' needs, making only critical investments now to ensure future reliability, security, and safety. UAMPS is still in the process of creating a rate structure for its customers. PacifiCorp continues to replace existing energy sources with those that are renewable. Importantly, Rocky Mountain Power doesn’t offer full retail rate for their net metering credits in Utah: as of 2021, customers receive a credit rate of about 6 cents per kilowatt-hour (kWh), or roughly half of the retail rate. They operate 75 generating plants across the West, including thermal, hydroelectric, natural gas, wind-powered, and geothermal facilities. PacifiCorp's generating plants have a net capacity of 10,887 megawatts. PacifiCorp currently has more than 1,400 megawatts of owned and contracted wind resources. Wind, hydro, geothermal and other non-carbon resources currently make up more than eighty-six (86%) percent of PacifiCorp's owned capacity. FIRST IC BANK First Internet Bank of Indiana First Intl. 3) PacifiCorp Energy operates a broad portfolio of power-generating assets to ensure low-cost energy is available for customers. Bank of Travelers Rest Bank of Utah Bank of Whittier Bank on Buffalo. 2) Rocky Mountain Power serves customers in Utah, Wyoming and Idaho. The company is comprised of three, business units working to provide safe, reliable electricity to customers at a reasonable cost: 1) Pacific Power serves customers in Oregon, Washington and California. The move proved detrimental to the solar sector, with developers claiming new applications for rooftop arrays dropped more than 90% in SRP's service territory.Rocky Mountain Power (a division of PacifiCorp) is one of the West's leading utilities, serving 1.8 million customers across 136,000 square miles in six western states. Utilities have proposed similar rate schemes, including residential demand charges on rooftop solar customers, but the critics have said demand charges in particular are hard for the average rate payer to understand.Īnd in 2015, Arizona's public power utility Salt River Project levied demand charges on solar customers. Rocky Mountain Power pays an average hourly rate of 74 and hourly wages range from a low of 64 to a high of 85. How can I pay my Rocky Mountain Power bill Make Online Payment Phone Payments Utility payments can be made by phone by calling 86. In Arizona, regulators are contending with a value of solar docket that could set precedents beyond its borders for solar rate reforms. In Nevada, a high-profile example, regulators last year slashed net metering rates and initially declined to grandfather in other customers, though a compromise between NV Energy and solar companies has since reversed that. The extent to which net-metered customers benefit or cost the utility grid is a contentious issue in states around the country. The utility is also proposing a new $60 application fee for most net metering customers to "cover the actual costs of processing the applications." RMP said its study showed residential net metering customers now receive bill savings worth about $0.105/kWh they produce, while the utility could purchase from large-scale renewable projects at about a third of the cost. "Over the next 20 years the cost shift to other customers is estimated to be about $667 million," the utility said in a statement. And RMP says that amount is forecast to grow to as much as $78 million annually if the issue is not addressed. The utility said it has conducted a study that shows a typical rooftop solar customer underpays their actual cost of service by about $400 per year, amounting to $6.5 million each year that is shifted to other residential customers. PacifiCorp subsidiary Rocky Mountain Power has proposed new rates for solar customers that would raise their bills and could make rooftop solar less appealing in a similar fashion to Arizona and Nevada. Utah appears to be the next battleground over compensating rooftop solar customers for their excess energy. The Stroop Test has been used in the neuropsychological assessment of executive functions in aging-related disease, such as Alzheimer’s Disease. In particular at neuronal level the altered function of cell cycle proteins may affect synaptic plasticity rather than cell duplication.The Cognitive Reserve concept, generally understood as the acquired protective effect, is considered by many authors as an active mechanism that is based on the application of previously learned resources, due to a good education, profession and/or premorbid intelligence. It is possible that p53 conformers may occur in the presence of misfolded molecules such as, but not limited to, beta amyloid. Moreover we found that the tertiary structure of p53 and the sensitivity to p53-dependent apoptosis are affected by low concentrations of soluble beta amyloid, the peptide that accumulates in AD brain but also present in peripheral tissues. As a result of such conformational change, p53 partially loses its activity and may become unable to properly activate an apoptotic program when cells are exposed to a noxious stimulus. Within this reference frame we studied p53 in aged controls and demented patients finding that with aging there is an increase of mutant like conformation state of p53 in peripheral blood cells, which is more pronounced in AD patients. The paper is mainly focused on one of such proteins, p53 which has been recently shown to be involved in aging and Alzheimers Disease (AD). Aging in higher animals may be influenced by the balance of cell survival versus death, a decision often governed by checkpoint proteins in dividing cells. Aging, dementia and cancer share a critical set of altered cellular functions in the response to DNA damage, genotoxic stress, and other insults. The latter two are the major contributors to illness burden for the aged. Altered response to drugs, cardiovascular and metabolic alterations, cancer and dementia are among the age associated ailments. Department of Experimental and Applied Pharmacology, University of Pavia, Viale Taramelli 14, 27100 Pavia, Italy.,ItalyĪbstract: In spite of the fact that the aging organism is the result of complex life-long gene/environment interactions, making peculiar the susceptibility to diseases and the response to drugs, pharmacogenetics studies are largely neglected in the aged.Title: Pharmacogenetics and Pharmagenomics, Trends in Normal and Pathological Aging Studies: Focus on p53Īuthor(s): C. Keywords: Pharmacogenetics, pharmacogenomics, aging, Alzheimer's disease, beta-amyloid, conformationally altered p53, biomarker In particular at neuronal level the altered function of cell cycle proteins may affect synaptic plasticity rather than cell duplication. In spite of the fact that the aging organism is the result of complex life-long gene/environment interactions, making peculiar the susceptibility to diseases and the response to drugs, pharmacogenetics studies are largely neglected in the aged. |